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INFOGEST static in vitro simulation of gastrointestinal food digestion

Brodkorb A, Egger L, Alminger M, Alvito P, Assunção R, Ballance S et al. INFOGEST static in vitro simulation of gastrointestinal food digestion. Nature Protocols . 2019 Apr 1;14(4):991-1014. doi: 10.1038/s41596-018-0119-1

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INFOGEST static in vitro simulation of gastrointestinal food

Using this method, food samples are subjected to sequential oral, gastric and intestinal digestion while parameters such as electrolytes, enzymes, bile, dilution, pH and time of digestion are based on available physiological data. This amended and improved digestion method (INFOGEST 2.0) avoids challenges associated with the original method ...

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Instituto de Biologia Experimental e Tecnológica Apartado 12, 2781-901 Oeiras, Portugal. and Instituto de Tecnologia Química e Biológica Universidade Nova de Lisboa Av. da República EAN 2781-901 Oeiras, Portugal. e-mail: [email protected] R. P. Singh Food & Function Page 4 of 22

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INFOGEST static in vitro simulation of

A standardised semi-dynamic in vitro digestion method suitable for food - an international consensus. This paper provides guidance and standardised recommendations of a physiologically relevant semi-dynamic in vitro simulation of upper gastrointestinal tract digestion, with particular focus on the gastric phase. Expand.

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The main strengths of static in vitro models are the good intra- and inter-laboratory reproducibility, robustness, simplicity, relatively low cost and easy assessment of each digestion phase. This latter point makes them quite suitable for mechanistic studies, hypothesis building and screening.

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A standardised static in-vitro digestion method …

Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, EAN Singh, R; University of California, Department of Biological and Agricultural

INFOGEST static in vitro simulation of gastrointestinal food digestion

Abstract. Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the …

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